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Phase 2 trial data showed no plateau at the 48-week endpoint
The loading phase (first 3 weeks) primes melanocytes and initiates tyrosinase upregulation, but meaningful photoprotection requires weeks 48 when melanin deposition accelerates
Lord et al., 2018)
Lactic Acidosis: Metformin can rarely cause a serious and life-threatening condition called lactic acidosis (too much lactic acid in the blood)
Place the syringe at a 90-degree angle to the shot site
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