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Obesity disrupts bone metabolism and leads to increased bone resorption, but GLP-1RAs can inhibit this damage and improve bone health by increasing the OPG/RANKL ratio, reducing osteoclast activity, and promoting bone formation
The American Diabetes Association similarly recommends at least 150 minutes of moderate-intensity exercise weekly, spread over at least 3 days, with no more than 2 consecutive days without activity
10.1158/0008-5472.CAN-10-3007 269
Its especially helpful for individuals with low B12 levels due to stress, aging, or dietary limitations
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