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Figure 1 Brain injury, mast cells, and inflammation Neuroinflammation plays central role in the CNS disorders such as MS, PD, AD, brain and spinal cord injuries, stroke, depression, schizophrenia, and chronic pain (Mcgeer and Mcgeer, 2010
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Other important factors include: Duration of diabetes : Longer disease duration is associated with greater beta-cell dysfunction, which may reduce the incretin-based response to DPP-4 inhibition Residual beta-cell function : As DPP-4 inhibitors rely on stimulating endogenous insulin secretion, patients with significantly impaired beta-cell reserve may respond less well Adherence to treatment : Consistent daily dosing is essential
And that might come as a surprise, but unless one considers the water content of the brain, which is very high, a lot of our brain and a lot of the integrity of the nerve cells, the so-called neurons in our brain, and the other types of cells comes from fat
