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N Engl J Med 2016;375:183444.ArticlePubMed 36
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This combination not only helps manage blood sugar levels but also lowers the risk of cardiovascular complications like heart attack and stroke
Furthermore, it modifies the antioxidant systems, including Superoxide dismutase (SOD), Catalase (CAT), and glutathione (GSH), resulting in increased ROS levels that adversely affect spermatogenesis and reduce fertility (103)
A) Once-daily long-acting insulin glargine (typically given at bedtime) achieves a steady-state within ~2 hours, does not display a distinct peak, and has a 20-24 hour duration of action in most patients
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