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Targeting one carbon metabolism with an antimetabolite disrupts pyrimidine homeostasis and induces nucleotide overflow

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From research on thymosin beta-4, TB-500 appears to modulate cell movement, differentiation, and tissue healing

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Buono R, Tucci J, Cutri R et al (2023) Fasting-mimicking diet inhibits autophagy and synergizes with chemotherapy to promote T-cell-dependent leukemia-free survival

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Loprinzi CL, Qin R, Dakhil SR, et al

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During this process, activated leukocytes produce large amounts of ROS as part of their mechanism to destroy invading pathogens

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