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This treatment method is used to treat MDD disorders ( BDNF ) ( Figure 1 Several different factors may contribute to depression such as stress, poor nutrition, insufficient exercise, obesity, chronic low-grade inflammation, smoking, atopic diseases, insufficient sleep, poor cleanliness, problems with dental care, and nutritional deficiencies, especially vitamin D insufficiency ( Firmicutes and Bacteroidetes ( The Microbiota-Gut-Brain Axis (MGBA) theory has advanced the most current depression hypothesis

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Oral dosing ranges discussed in research community use Phase Weeks 12 (start low) Daily dose 50 mg once daily Notes Morning dosing is the pattern most often reported

doi: 10.1007/s00203-025-04280-9 18 Kraut-CohenJ.ShapiroO