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Tirzepatide layers GIP-receptor agonism on top, which is the molecular feature distinguishing it from semaglutide, liraglutide, and dulaglutide all of which are GLP-1-selective
CJ: Theres a chance you may be
Significantly greater reductions in HbA1c from baseline to week 26 were reported for all doses of oral semaglutide except the 3 mg dose compared to sitagliptin
That advantage is real, but its also replicable
Lifestyle changes Though sometimes an overlooked footnote, trials for semaglutide (like this one of more than 1,900 adults published in 2021) included lifestyle intervention for both the placebo and medication group
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