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1024 Additionally, the novel compounds TVB-3664 and TVB-3166 demonstrated antitumor effects in laboratory and animal studies, but further clinical trial data are needed

European Journal of Clinical Pharmacology

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Previously, we showed that TG2 mediates crystallin, caspase 3, and collagen crosslinking in response to oxidative stress, hypoxic stress, and DNA damage, which leads to cataract formation, apoptotic resistance, and fibrotic development, respectively 4,5,6