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Furthermore, PKA-mediated phosphorylation of serine 730 (S730) residue in CUL5 enhances its neddylation efficiency and nuclear localization, potentiating its anti-proliferative effects ( 3.4.2 The NEDD8/CUL5/NOXA axis NOXA (Phorbol-12-myristate-13-acetate-induced protein 1), a pro-apoptotic protein (89), modulates cell death by influencing the ubiquitination and degradation of itself through CRL5, which is regulated by key molecules in the CUL5 neddylation process

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There have been anecdotal reports of some patients using these drugs for weight loss and then presenting with repeated episodes of nausea and vomiting secondary to a condition referred to as gastroparesis, Mahyar Etminan, the studys senior author and an epidemiologist and ophthalmology and visual sciences professor at the UBC Faculty of Medicine, said in a statement

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