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The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)
In healthy adults the total concentration sits around 200 to 600 pmol/L, but the upper reference limit varies by laboratory and by analytical platform
2015;308:E9901000
M., Fahmy, S
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