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doi: 10.1210/endocr/bqab065 4 ZilstorffDBRichterMMHannibalJJrgensenHLSennelsHPWewer AlbrechtsenNJet al
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Interestingly, DMF was found to induce cysteine biosynthesis 26 , elevate cellular GSH levels 27 , and present an NRF2-independent effect through posttranslational protein succinylation 28,29
Similarly, the closed-state structures of GluK2 bound to the non-competitive inhibitor antiepileptic drug perampanel (Gangwar et al., 2023b), or polyamine blockers (Gangwar et al., 2024a), all solved in the presence of BPAM, displayed the same canonical two-fold symmetrical dimer-of-dimers arrangement of LBDs (Figures 7CF)
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