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Regardless of the precise mechanisms contributing to this phenomenon, a growing appreciation is that the central nervous system (CNS) is sensing multiple changes in redundant hormonal systems that drive hyperphagia to restore a previous body weight set point 54

Following the success and approval of tirzepatide (Mounjaro, Eli Lilly, Indianapolis, IN, USA) in 2022 by FDA for treatment of T2DM, the SURMOUNT programme investigated its use as an anti-obesity medication in those without diabetes