NNMT acts as a primary metabolic gatekeeper, predominantly active in fat tissue and liver cells, where it methylates nicotinamide (NAM) using S-adenosyl-L-methionine (SAM) as a methyl donor
Advantages : Allows for the delivery of higher doses in a single injection, reducing the need for multiple injections
Published in vitro and animal-model research has examined NNMT inhibition in connection with several areas of scientific interest, including adipocyte metabolism , NAD pathway regulation , mitochondrial function , and cellular energy signalling
It means that anyone using it should understand they are in largely uncharted territory and proceed with appropriate caution and monitoring
For example, people who maintain a vegetarian or vegan diet, people with absorption disorders, and those taking prescription meds like Metformin, Proton Pump Inhibitors (PPIs), and H2 blockers like Pepcid are often at greater risk