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Safety considerations include pregnancy and breastfeeding status, existing medical conditions, and concurrent medicines
Based on Phase 2 trial data, retatrutide's side effect profile appears broadly consistent with other incretin-based therapies, though the addition of glucagon receptor agonism introduces some distinct considerations
Cholesterol and blood pressure also improved in those taking the drug
The demand for GLP-1 analogue manufacture is greatly influenced by the fact that the US leads the world in pharmaceutical research and development, particularly in the fields of diabetes and obesity treatments
doi:10.1016/S0140-6736(21)01324-6 96
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