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doi: 10.1155/2023/8929525 114 DixonSJPatelDNWelschMSkoutaRLeeEDHayanoMet al
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Protein supplementation combined with resistance training leads to greater preservation of lean mass and strength than training alone. Key point: With adequate protein intake and resistance training, patients can maintainand sometimes increasestrength during GLP-1 therapy despite overall weight loss. Recovery and micronutrients Adequate sleep, hydration, and correction of deficiencies (including vitamin D when present) further support muscle function and recovery. Bottom Line: GLP-1 Medications Improve Body Composition Not Muscle Wasting Semaglutide and tirzepatide do not inherently cause muscle wasting. Most weight lost is fat , and body composition improves. Muscle wasting is primarily a risk of undernutrition , not GLP-1 therapy itself. Protein + resistance training is the most effective strategy to preserve muscle. At Potere Health MD, GLP-1 and GIP therapy is paired with evidence-based nutrition and strength guidance so weight loss is healthier, stronger, and more sustainable
Some practitioners theorize that establishing robust GLP-1-supporting gut bacteria before discontinuing medication could provide a partial buffer against rebound effects, maintaining some degree of natural GLP-1 production even after the pharmaceutical support is removed
Peroxiredoxins There are peroxidases that catalyze the reduction of hydrogen peroxide, organic hydroperoxides, as well as peroxynitrite
