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This warning stems from preclinical studies in rodents that demonstrated dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures

Insert the needle into the vial and push the plunger to inject the air

To validate these findings, we examined the protein levels of key NOTCH pathway components (HEY1, HES1, and NOTCH1) by Western blot in LUAD cells with SLC25 A39 knockout (koSLC25 A39) and overexpression (oeSLC25A39)

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Quantitative proteomics strategies can compare changes in crotonylation levels under different treatment conditions or in different tissue samples, thereby revealing the dynamic regulation of crotonylation under specific physiological or pathological conditions