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Triple-agonist means targeting GLP-1, GIP, and glucagon receptors

The review documented GLP-1s rapid inactivation by DPP-4 even before the hormone has left the gut raising the hypothesis that GLP-1s actions may be partially transmitted via sensory neurons in the intestine and liver expressing the GLP-1 receptor rather than solely through systemic endocrine circulation

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GLP-1 receptor agonists slow gastric emptying, alter gut motility, and reshape the microbiome environment over time