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Even more serious is that B12 deficiency can disturb red blood cell formation and elevate homocysteine levels, which negatively impacts neurological and cardiovascular health, in addition to posing risks during pregnancy

Mouse studies reported changes in adiposity, glucose handling, liver pathology and muscle-function measurements

Per the CMS Claims Processing Manual , billing the J-code when the practice did not supply the drug is a billing error

Nevertheless involvement in the audit stimulate a considerable change in behaviour among participating doctors, leading to subsequent improvement in their use of vitamin B12

(PubMed) Watkins D, Rosenblatt DS