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In recent years, extensive literature has reported that a variety of signaling pathways and transcription factors are involved in the fat differentiation process of WAT, such as the NOS pathway, neuropeptide S [87] pathway, SIRT1 [88] pathway, STAT3 [89], bone morphogenetic protein 4 (BMP4) [90] pathway, etc

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demonstrated that weekly administration of either GLP-1 RA semaglutide or dulaglutide produces a rapid, substantial and dose-dependent reduction in EAT thickness [37], that may bring to a reduction in the pro-inflammatory stimuli

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