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patent landscape

SUMOylation, a PTM characterized by the covalent attachment of small ubiquitin-like modifier (SUMO) proteins to target proteins, plays a crucial role in diverse cellular processes and serves as a vital cellular mechanism for stress response

The mechanism of action is attributed to the GIP/GLP-1 receptor co-agonism being enhanced by glucagon receptor activation and augmentation of energy intake, substrate utilisation and energy expenditure [60]