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Do not restart at a higher dose after an illness-related pause

That pattern is consistent with prescribing information describing gastrointestinal adverse reactions during escalation

PMID: 32615074 12 Trimethylaminuria In A 58-Year-Old Male with Liver Cirrhosis and Hepatitis C

Optimal lipid balance involves hepatic cholesterol synthesis and clearance, lipoprotein structure and particle size, triglyceride metabolism, inflammation, insulin sensitivity, and body composition all of which are influenced by peptide signaling

But if side effects suppress intake so patients undereat or miss nutrients, hypoglycemia or feeling undernourished can provoke: Irritability Anxiety Depression Watch for wide swings in glucose or persistent poor intake after starting the drug, because those physiologic changes can feed emotional symptoms