However, if that same individual comes in and they go, you know, I have sleep apnea, my knees hurt, I'm developing pre-diabetes, or a woman has PCOS, infertility and so forth now there's harm to their health because of the excess body fat, and we call that clinical obesity
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The researchers acknowledged that the study was limited by its small human sample size and the use of exclusively male mice
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TGF-1 is a cytokine that reduces the expression of PPAR- and the PPAR- coactivator-1a (PPARGC1A) with consequently reduced expression of CPT1 and of the FAO enzyme Peroxisomal acyl-coenzyme A oxidase 1 (Acox1) which catalyzes the desaturation of acyl-CoAs to 2- trans- enoyl-CoAs