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45 Interestingly, a study also shows that NADPH level is not changed by silencing PGD expression, which is possible that a temporally increased NADP + /NADPH ratio compensatory increased G6PD activity, thus generating NADPH

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doi:10.4049/jimmunol.1801180

Consistent with enhanced glutathione production, melatonin-treated ILC2s exhibited increased expression of GCLC and GCLM, enzymes that catalyze the rate-limiting steps in glutathione synthesis ( Figures 6E, F )

"N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility." Expert Opin Biol Ther