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Either Trx and TrxRD are expressed as isoforms for both predominantly cytosolic (Trx1 and TrxRD1) or mitochondrial (Trx2 and TrxRD2) localization (Orrenius et al., 2007)

Pharmacokineticpharmacodynamic modeling in healthy volunteers demonstrated that the peptide is rapidly absorbed , producing a measurable increase in GH concentrations shortly after administration without significantly altering levels of other hormones such as cortisol or prolactin