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effects on fat metabolism in humans are still being characterised and should not be overstated Glucagon receptor increases energy expenditure and promotes fat breakdown, though it may also raise hepatic glucose output

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To serve global markets effectively and equitably, the pharmaceutical industry also needs to maintain a balanced R&D portfolio that meets the broad needs of society

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), notably the long-acting agonist semaglutide, exhibit significant metabolic efficacy and pronounced neuroprotective effects across a broad spectrum of preclinical models

Graziano and Gonzalo 2017)