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The last GSH synthetic process is the one depending on the conversion of the oxidized dimer GSSG to 2 reduced GSH molecules in cells by glutathione reductase (GR), an ubiquitous enzyme of the family of disulfide reductases, in the presence of NADPH and flavin adenine dinucleotide -FAD-
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Conclusions Treatment with glutathione significantly improved ALT levels
Elevated ROS levels are a hallmark of leukemia cells, resulting from molecular mechanisms involving NADPH oxidase, the mitochondrial electron transport chain (mtETC), and cytochrome P450 [34, 90]
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