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The theoretical isoelectric point and molecular weight were obtained using the ExPasy website ( 3 Feasibility of CPP-mediated nasal drug delivery 3.1 Characteristics of nasal administration route in the drug delivery Mucociliary clearance refers to the clearance of the mucus and substances that are adsorbed in the nasal cavity or dissolved in the mucus, pushing it into the gastrointestinal tract through nasopharynx ( via nasal routes for systemic effects ( The choice of nasal route for drug administration is mainly determined by considering the physicochemical properties of drugs, including hydrophobicity and molecular size ( To overcome the above-mentioned hurdles of intranasal drug delivery, peptides and proteins can be modified to increase their membrane permeability and stability, by supplementing the drug with enzyme inhibitors that perturb the pseudo-first-pass effects ( 3.2 Pathways of transepithelial transport To reach the bloodstream on the capillaries, drugs have to pass through the mucus barrier