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Trends Pharmacol Sci 11: 161166
Discussion Genetic fusion of protein-based drugs to the N-terminal or C-terminal end of albumin, or both, offers a feasible and attractive approach to enhance the PK properties and therapeutic efficacy of short-lived biologics 6,7
In these reactions GSH is oxidized to GSSG and the ratio [GSH]/[GSSG], an indicator of the redox status of the cell, is known to regulate redox sensitive enzymes in the pathways for cell proliferation and cell apoptosis [5]
Baltrons MA, Pedraza C, Sardn T, Navarra M, Garca A
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