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Most providers suggest a slow titration processgradually increasing the doseto help your body adjust to the combination
Regulatory Status: Zepbound is FDA-approved
Missing data at Week 72 due to early treatment discontinuation, initiation of prohibited medications or bariatric surgery or other weight loss procedures were assumed to be missing at random
More recent research, however, has suggested that GLP-1 agonists may not increase the risk of ileus or intestinal obstruction
Tierney, E
![Efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1](https://www.researchgate.net/publication/363201315/figure/fig3/AS:11431281082605778@1662084799021/Efficacy-of-tirzepatide-in-phase-2-GPGB-14-and-phase-3-SURPASS-1-to-5-15-19.png)
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