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The dosage of most hypoglycemic medications is gradually increased, if needed, according to a prescribed dosing schedule and therapeutic glycemic targets or until maximal dosage is reached
Small-molecule administration After shaving the backs of 7-week-old C57 mice, 100 l of 400 M KYP-2047 (T8657, Taojiao, China), 8 mM SMER28 (T3155, Taojiao, China), 200 M Pennogenin 3-O-beta-chacotrioside (T8166, Taojiao, China), or dimethyl sulfoxide (BS087-100 ml, Biosharp, China) was applied to the lower left part of the back of the mice
Therefore, DNA methylation biomarkers can serve as indicators for the pathogenesis and early screening of GC
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