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As one of the most impactful classes of drugs in recent history, these medications have the potential to dramatically improve the rates of cardiovascular disease in the U.S. Cheng-Han Chen, MD Future research should evaluate the possible mechanisms behind how GLP-1 agonists offer cardiovascular protection beyond their effects on weight loss and blood sugar control, he added.

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The mechanism explains it: two complementary hormonal pathways, each cutting calorie intake and fat storage through distinct routes, produce results neither could reach on its own

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The concept of incretin effect was first proposed by Creutzfeldt in the 1970s ( 2 Physiology of incretins 2.1 Discoveries of GIP and GLP-1 The first incretin, GIP, was purified from canine intestinal extracts in the late 1960s ( + secretion ( Figure 1 Section A]

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Some programs bundle care and medication

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