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[6] These analyses are useful, but they are the weakest tier for a two-drug verdict: indirect comparisons inherit every difference between the underlying trials and cannot substitute for a randomised head-to-head
* Based on the trial product estimand: estimated efficacy in an idealized scenario in which all patients stayed on treatment and took no other weight loss therapies
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Serious concerns revolve around severe skin reactions and potential injury to the liver and kidneys
This is a type of post-translational modification known as S-glutathionylation, which protects proteins from irreversible oxidation, but can disrupt their function
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