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Additionally, in vitro research has verified that IL-1 directly promotes osteoclast survival, multinucleation, resorption activity, and formation (59)
At species level, the downregulation of the hexitol fermentation to lactate, formate, ethanol and acetate pathway was mainly due to Lactobacillus salivarius , with a significant decrease in T2 and T4 compared to T1, whilst the stachyose degradation pathway was down regulated in L
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