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Excess ROS, if not detoxified by antioxidants, can lead to irreversible genomic damage, lipid peroxidation, persistent mitochondrial dysfunction, and activation of aberrant signaling pathways, resulting in cellular mutation, chromosome instability, and neoplasm initiation (Milkovic et al., 2014)
Spermine is an endogenous iron chelator that inhibits ferroptosis
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Due to its protein content and muscle recovery benefits, it is also useful for those who exercise regularly
Materials and methods Animals and treatments DHEA-induced PCOS in rats was created with subcutaneous administration of DHEA at a dosage of 6 mg/100 g/day for 34 days
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