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Important safety considerations include a boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), and warnings for pancreatitis, gallbladder disease, acute kidney injury, and severe gastrointestinal disease
Back to the future with ubiquitin
Nat Rev Endocrinol 16(9):506518
May 2026 Volume 92 Issue 5 Oral GLP-1 Orforglipron Is Approved for Obesity Kennedy Ferruggia, Associate Editor Kelly King Key Takeaways Orforglipron enables unrestricted oral dosing independent of food and water, potentially improving real-world adherence compared with peptide-based oral GLP-1 therapies with absorption-driven administration constraints
More importantly, it is unknown whether exendin-4 has any effect on adiponectin expression in vivo
