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Although there is theoretical concern that collagen and gelatin (including gelatin capsules) derived from cows could be contaminated with the infectious agent that causes mad cow disease, these ingredients are not derived from high-risk tissue and are subject to regulations that make this unlikely

While some patients tolerate treatment well when appropriately evaluated, safety depends on individual health status, medications, and clinical judgment

It also helps promote the activity of other antioxidants

753483) and were maintained at 37 C in a humidified incubator with 5% CO 2