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I take two lessons from this story

The anti-fibrotic effects of GLP-1RAs may arise from their ability to improve metabolic control, reduce body weight, and directly affect HSCs

In the Pancreas: GLP-1 stimulates insulin secretion in a blood glucose dependentmanner hence decreasing B cell over function, enhancing Beta-cell survival rate, decreasing B- cell apoptosis and preserving B-Cell mass

FIGURE 1 Within the SCN, Per paralogs function as the state variable such that variations in the levels of proteins account for the phase of the clock (Kim et al., 2018)

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