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Any protocol combining them sits outside the evidence base of randomized trials

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Additionally, investigating the formulations effectiveness in pediatric populations and individuals with neurological conditions could provide further insights into its benefits and safety profile

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Identification of the exact mechanism for the lethal effect of silencing the enzyme requires further experiments, as do the effects of inhibitors, which are not necessarily solely due to loss of enzyme activity, because the inhibited enzyme may also have a gain of function leading to cell death [72]