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GLP-1 receptor agonists e.g., semaglutide, liraglutide commonly cause gastrointestinal adverse effects such as nausea, vomiting, diarrhea, constipation, and abdominal discomfort, especially during dose escalation, less common risks include pancreatitis, gallbladder disease, and hypoglycemia mainly with insulin sulfonylureas
Epithalon is used in short, defined cycles rather than continuous daily use
In practice, vial expiration and sterility concerns mean most prescribers recommend using a vial within 28 days of first puncture
They create energy (ATP), but this process also creates byproducts that can damage the mitochondria themselves
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