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These findings compel further research to understand how mitochondrial metabolism and the related epigenetic programming of brain plasticity can serve as new targets to develop mechanism-based treatment models for psychiatric and neurodegenerative diseases

Dugue PA, Hodge AM, Ulvik A, Ueland PM, Midttun O, Rinaldi S, MacInnis RJ, Li SX, Meyer K, Navionis AS, et al

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In-vitro fibroblast studies indicate that GHK-Cu upregulates transcription of collagen and elastin genes and supplies copper as a cofactor for lysyl oxidase, the enzyme that cross-links these matrix proteins