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The FDA may take extra time to evaluate the glucagon-related safety signals, particularly the heart rate increase (up to 6.7 bpm above baseline) and dysesthesia (Nature Medicine, 2024)
When used appropriately, GLP-1 analogs have been shown to be safe
Of course, some muscle loss is expected with any form of weight loss
For people with more subcutaneous fat, the layer may be 15-20mm or deeper, making it nearly impossible to accidentally inject into muscle even at a 90-degree angle
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