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Immunoglobulins from patients with Graves disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-I receptor

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Dementia and depression have been associated with this deficiency as well, possibly from the under-production of methionine because of the inability to convert homocysteine into this product

Hu LH, Yang JH, Zhang DT, Zahng S, Wang L, Cai PC, Zheng JF, Huang JS: The TKTL1gene influences total transketolase activity and cell proliferation in human colon cancer LoVo cells

NNMT knockdown in WAT and liver protects against diet-induced obesity by augmenting cellular energy expenditure