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[1] [2] The pivotal SUSTAIN trials, which evaluated semaglutide for type 2 diabetes, and the STEP trials for weight management did not identify cold intolerance as a statistically significant adverse event

Beyond metabolic slowing, patients may experience fluid retention, decreased fat breakdown, and alterations in appetite-regulating hormones

Wilding, D.M

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As with any topical treatment, users should monitor their skin for any signs of irritation or adverse reactions and report these to their healthcare provider immediately