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In substance use disorders (SUDs), this issue presents as increased craving, impaired control, and heightened responses to cues
Its role is to: Enhance insulin secretion when blood sugar rises Reduce glucagon secretion , lowering blood glucose production Slow stomach emptying , which promotes satiety Reduce appetite , leading to weight loss Since natural GLP-1 breaks down quickly, drug companies created synthetic GLP-1 receptor agonists (like semaglutide in Ozempic/Wegovy) that stay active longer
10.1016/s1499-3872(11)60085-4 106 WangW.GuanC.SunX.ZhaoZ.LiJ.FuX.et al (2016)
ChaC2 may exert a tissue-specific function, promoting the survival of tumor cells in specific contexts (50,81,82)
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