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GSH extrusion and the mitochondrial pathway of apoptotic signalling
Patent filings have concentrated on sequence optimization, receptor balance, and dosing regimens [5, 6], while scientific reviews increasingly position these compounds as the next frontier beyond single-target GLP-1 therapy [1, 2]
it was developed in 1995 and approved for marketing in 2005
Notably, while most studies indicate that cysteine modulates ferroptosis via its role in GSH synthesis, inhibiting GSH synthesis alone is insufficient to induce ferroptosissuggesting that cysteine may also regulate this process through alternative metabolic pathways (85)
GLP-1 medications are usually started at low doses
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