Medications that influence appetite, metabolism, and insulin signaling affect multiple organ systems
ACHIEVE-3 was the head-to-head trial against oral semaglutide in T2D (1,698 patients, 52 weeks), showing orforglipron superiority
We felt it was important to document her clinical course to inform clinicians facing similarly complex patients. Indeed, children with early-onset obesity develop insulin resistance, liver dysfunction, and beta cell decline much more rapidly than adults because their organs and metabolic systems are developing, which makes them more vulnerable to the harmful effects of excess adiposity
That is, until other users began sharing similar stories
Although both molecules share a remarkable ability to reduce body weight and HbA1c levels, they differ in their mechanisms of action, current therapeutic indications, and the robustness of available evidence on cardiovascular outcomes