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And while these trials are important to understanding the safety and efficacy of drugs, "no randomized controlled trial" is not the same as "no evidence." We have the accumulated experience of thousands of clinicians who have prescribed these compounds for nearly a decade and watched real patients get better in real time
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One hypothesis from researchers at Harvard Medical School: chronic NNMT suppression might alter methylation donor availability, since NNMT consumes S-adenosylmethionine (SAM) as a methyl donor
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