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The target pathway under investigation direct lipolysis, receptor-mediated signaling, or upstream hormone stimulation is typically the deciding factor in which compound class fits a given research design

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Finally, while rodent models demonstrate compelling proof-of-concept (e.g., SCFA supplementation ameliorates OA), the translatability of these findings to human physiology, with its greater complexity and longer disease course, is a significant hurdle that future research must overcome (30)