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As a genetically modified herpes simplex virus-1, T-VEC has a novel mechanism of action achieved via several genomic modifications to attenuate neurovirulence, increase specificity for cancer cells, enhance antigen presentation, and stimulate the immune response by insertion of the gene for human granulocytemacrophage colony-stimulating factor (GM-CSF).1 The randomized open-label phase III trial comparing T-VEC to GM-CSF injections, known as Oncovex GM-CSF Pivotal Trial in Melanoma (OPTiM), demonstrated a superior and significant durable response rate (complete response (CR) plus partial response (PR) lasting 6 months) in the T-VEC arm (19.3% vs 1.4%) as its primary endpoint.2 3 CR and PR were achieved in 16.9% and 14.6%, respectively, and median time to CR for those who achieved it was 8.6 months

If these studies do evidence these wider benefits, the case for wider public coverage of OMs will be greatly strengthened

10 Given the high prevalence of obesity and metabolic syndrome in patients with HS as well as the anti-inflammatory effects of GLP-1 RAs, these agents may offer therapeutic benefits in HS

Phase 3 RCT (2024) : Chinese multicenter trial (n=458) demonstrating significant improvement in modified Toronto Clinical Neuropathy Score with ALC 1,500 mg/day vs