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One key effect is delayed gastric emptyingyour stomach moves food into your intestines more slowly, keeping you fuller for longer
The UK SmPCs for Wegovy (semaglutide 2.4 mg) and Mounjaro (tirzepatide), available via the Electronic Medicines Compendium (EMC), provide detailed information on GI adverse reactions and class-related warnings such as pancreatitis and gallbladder disease
[2] [3] Other gastrointestinal effects include nausea, vomiting, constipation, and abdominal pain
Tirzepatides dual-action mechanism works differently than semaglutide, and some people see renewed progress after switchingthough individual responses vary
[ 2 ] Interestingly, a 2025 mouse study did test an experimental semaglutide patch and found it caused weight loss and boosted metabolism compared with injections
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